Most a short while ago, it's been recognized that conolidine and the above derivatives act about the atypical chemokine receptor three (ACKR3. Expressed in identical regions as classical opioid receptors, it binds to some big … Read More

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Conolidine’s analgesic effects stem from its interaction with non-opioid pain pathways. Contrary to opioids, which bind to µ-opioid receptors from the central nervous method, conolidine modulates alternate molecular targets. A… Read More